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Technology Raman spectroscopy
 
Protection strategy Product authentication
Type Analytical technique
System Laboratory based
Medium Medicine : pills, bulk product, liquid
Authentication/Identificaton Authentication
Traceability No
Cost Price on request
Required equipment Raman spectroscopy apparatus
Vertification level Laboratories
N.B.
Description Raman spectroscopy can identify many active ingredients and give further information about excipients, as well as the relative concentrations of active ingredients to excipients.
A monochromatic light beam is directed on the sample. The majority of the light beam is transmitted through the material, and a minor part is released. By analyzing the scattered light and the peak detection at certain wavelengths (distinct from the wavelength of the incident beam), the chemical composition of the sample can be deduced. Usually the identification of the different compounds is done by comparison of the produced spectrum with a database of reference spectra.
 
Strengths Objective analysis of the product (contents analysis);
Non destructive;
Analysis any form of medicine (pills, liquid);
Gives relative concentrations of API to excipients;
 
Limitations Requires specific equipment: the device and some training for the person who is manipulating the apparatus;
Cost;
Titanium oxide, cellulose and its derivatives on coated pills produce fluorescence and therefore interfere with Raman signals;
Not portable;
 
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