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Technology Nuclear Quadrupole Resonance spectroscopy –
The Conphirmer system
 
Protection strategy Product authentication
Type Analytical technique
System Portable device
Medium Medicine
Secondary packaging
Authentication/Identificaton Authentication
Traceability No
Cost Price on request
Required equipment Conphirmer system
Vertification level Authorities;
Laboratories
N.B.
Description Development stage – The CONPHIRMER consortium proposes to produce a portable system for the authentication and identification of counterfeit drugs using a form of radio-frequency spectroscopy related to Magnetic Resonance Imaging (MRI). The particular form of radio frequency spectroscopy utilized is based on Nuclear Quadrupole Resonance spectroscopy (NQR).
This consortium aims to develop a robust, economical, user-friendly and portable instrument for the non-invasive and non-destructive screening of packaged pharmaceutical products that will aim to give the operator an answer as to whether or not the packaged product is genuine or counterfeit in less than one minute. QR is a radiofrequency (RF) spectroscopic technique that can detect signals through multiple layers of cardboard, glass, plastic and/or wood. QR can analyze any compound containing a quadrupolar nucleus, which accounts for over 50% of elements in the periodic table, and, in particular, it is ideally suited for the analysis of compounds containing nitrogen, chlorine or bromine, sodium and potassium, which includes over 80% of all drugs.
Authentication level: the apparatus is equipped of a barcode reader and the QR analyzer, the authentication is based on a match content/container, the match between the barcode and the analyzed product. The match would determine if the product is genuine or fake (green/red light). This authentication would only take few seconds. A longer analyze of the product could produce a more complex answer, indeed the QR analyzer could identify and quantify the different compounds of the products. A database with the spectra of the different products will be necessary for the authentication and identification of each product.
 
Strengths System can analyze dry powder (including capsules) and oral suspension;
Allow authentication and identification of the product;
Portable;
Instant authentication;
No training needed;
Guarantee product integrity thanks to the match packaging/medicine (container/content);
Non destructive (do not even need to open the box);
Allow the quantification and qualification of the compounds;
 
Limitations Cannot be used on liquid,
At the tableting level: for each manufacturer the fingerprint of the product is different which means than a different profile needs to be added to the database for each product produce by different manufacturers;
Cost;
 
  Links:http://www.conphirmer.eu/pages/project/concept.html

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