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Technology Ion Mobility Spectrometry
 
Protection strategy Product authentication
Type Analytical technique
System Portable device
Medium Medicine
Authentication/Identificaton Authentication
Traceability No
Cost Price on request
Required equipment IMS apparatus
Vertification level Authorities;
Laboratories
N.B. Smiths, Thermedics
Description Ion Mobility Spectrometry, or IMS, is an instrumental analytical method. A solid or liquid sample (only few nanogram needed) is introduced to the analyzer by thermal desorption or direct injection. The resultant vapors are swept in through the inlet by the carrier gas and ionized. Ionized molecules travel through a drift tube at distinct speeds that are related to their mass and geometry. We obtain a plasmagram that can be compared to reference spectra. The device is portable and some model do not need an electrical outlet.
 
Strengths No sample preparation;
Low quantity of sample needed (few nanogram);
On liquid and solid;
Identification of the different constituents of a sample: provides information about the distribution of active ingredients and excipients on the surface of the tablets;
Can be used for profiling;
Can be used in situ;
 
Limitations Cost;
Requires equipment + formation;
Destructive of the sample;
Portable in most case but not easily transported;
Need a power source in most cases;
Need to build a library of reference spectra;
 
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