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Technology Capillary electrophoresis
 
Protection strategy Product authentication
Type Analytical technique
System Laboratory based
Medium Medicine
Authentication/Identificaton Authentication
Traceability No
Cost 8’000 € for the ECB (budget capillary electrophoresis)
Required equipment CE apparatus + computer
Vertification level Laboratories
N.B. ECB: reliable low-cost capillary electrophoresis device for drug quality control and counterfeit medicines, developed by Swiss Universities. Marini RD
Description Capillary electrophoresis is an analytical technique that separates ions based on their electrophoretic mobility with the use of an applied voltage. A small amount of sample is dissolved in a specific solvent. The sample components move at different rates in a capillary filled with an electrolyte thanks to the applied voltage and the interaction with the electrolyte. Then, they are detected at the end of the capillary by either a UV/visible spectrophotometer or a mass spectrometer.
The ECB (budget capillary electrophoresis): The analysis takes 20 minutes on average. First of all the drug is solubilized with water. A small quantity of the substance is set in motion by an electrical pulse, then moves along in a capillary. Using ultraviolet rays, the device measures the duration of the drug’s journey, which is recorded on a normal laptop computer.
 
Strengths Qualify and quantify organic compounds, PI, proteins and amino acids;
Robust;
Easy to use (minimal training);
Can be used for profiling;
Advantage of the ECB is that it uses a minimum dose of solvent (barely a millionth of a liter) per analysis;
 
Limitations Destructive;
Need a library of reference spectra;
 
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